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LSM 880 Confocal Microscope Picture
LSM 880

Revolutionize your confocal imaging by entering a new world of performance and capability - also coupled with Airyscan super resolution.  

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Airyscan White Paper

Revolutionize Your Confocal Imaging with Airyscan

Your samples tend either to be very small, move very fast or bleach very quickly. Or do all of that at once. To get unbiased data from live cells or other weakly labelled samples, there's no such thing as too much sensitivity, resolution or speed. Each photon of emission light is precious.

Now you can use multicolor samples with any label and get image quality like you’ve never seen before. With Airyscan you are always able to select the optimal acquisition strategy for your sample: Simply decide whether you want to gain 1.7x higher resolution in all three dimensions – resulting in a 5x smaller confocal volume. Or push the sensitivity beyond the limits of all conventional confocals. Or use the increase in signal-to-noise ratio to speed up your image acquisition. The choice is yours.

With Airyscan You Enter a New World of Confocal Performance

  • Use a true confocal that gives you high sensitivity, improved resolution in x, y and z, and high speed in one system
  • Increase the resolution of your imaging: with Airyscan you resolve 140 nm laterally and 400 nm axially, at 488 nm
  • In the optional Virtual Pinhole Mode, you can decide even after the acquisition, which pinhole size best suits your application

 

Perform Quantitative Imaging

  • Perform gentle imaging of your samples, thanks to the homogeneous illumination with linear scanning, combined with a sensitive detection infrastructure
  • Working with identical pixel times and continuous scanner monitoring, you perform quantitative imaging at all speeds and scan modes
  • Get robust and reliable results, even from your most demanding single molecule imaging and analysis

Increase Your Productivity

  • Save time on investigations into localization and interaction of proteins that require multiple labels: You collect all these signals in one go
  • Perform simultaneous spectral detection in a single scan with the highest number of descanned or non descanned channels – including GaAsP technology
  • Take full advantage of large fields of view and the highest speed of any linear scanning confocal – up to 13 fps

Your Powerful Combination

To fully resolve the movement of labeled proteins in dynamic cellular and subcellular processes you often need to image at around 10 frames per second. Now, with LSM 880, you can achieve up to 13 frames per second at 512 x 512 pixels.

LSM 880 is constantly monitoring and calibrating the scanner position to guarantee a stable field of view and equal pixel integration times over the whole field of view. Linear scanning is an essential prerequisite for your quantitative and correlative imaging. It gives you a constant signal-to-noise level and uniform exposure to the illuminating laser throughout the scanned area, including manipulated regions of interest. Unlike traditional sine scanning confocals, LSM 880 uses more than 80% of the scanning time for data acquisition. That means you will enjoy a 29% improvement of signal-to-noise ratio because of longer pixel integration times at a defined frame rate.


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